GSH‐Responsive Dnase‐I‐Loaded MnO _<i>x</i> Nanoplatforms for Combined Protein‐Chemodynamic Therapy

The effective delivery of protein therapeutics remains a major challenge. Here, the novel nanoplatforms with bovine serum albumin (BSA)-coated, Dnase-1-loaded MnOx nanoflowers are developed (denominated MD@BSA). These MD@BSA present highly efficient loading and Dnase-I into tumor cells. Under glutathione (GSH) overexpression environment, is degradable, resulting in Dnase-1 Mn2+ release for combining chemodynamic therapy (CDT), GSH-responsive MR imaging vivo vitro that could be used to trace evaluate severity therapeutic regimen adjustment. This method offers facile strategy both delivering proteins enhanced treatment effect via combined protein-CDT, which may contribute clinical application future.